Step 1: Press the Win + I keys on your keyboard to open the Settings app. In Windows 10, you can go to Windows Settings to uninstall Malwarebytes. Uninstall Malwarebytes via Windows Settings Step 4: Confirm the uninstallation operation and the process starts. Step 3: In the Programs and Features interface, right-click Malwarebytes and choose Uninstall/Change. Step 2: Click Uninstall a program from the Programs section.